Which enzyme is primarily involved in the conversion of 7-dehydrocholesterol to vitamin D3?

Which enzyme is primarily involved in the conversion of 7-dehydrocholesterol to vitamin D3?

• A. Cytochrome P450
• B. 7-dehydrocholesterol reductase
• C. Hydroxylase
• D. Aldose reductase

Answer: (C)

The conversion of 7-dehydrocholesterol to vitamin D3 primarily involves the action of UV light rather than a specific enzyme. When skin is exposed to sunlight, specifically ultraviolet B (UVB) radiation, 7-dehydrocholesterol undergoes a photochemical reaction to form previtamin D3, which then spontaneously isomerizes to vitamin D3 (cholecalciferol) at body temperature. While hydroxylase enzymes are essential in the subsequent steps that convert vitamin D3 into its active forms in the liver and kidney, the original conversion from 7-dehydrocholesterol to vitamin D3 is not enzyme-mediated but rather a light-driven process. Therefore, while hydroxylases play crucial roles in the metabolic pathway of vitamin D, particularly during hydroxylation of the molecule in later steps, they do not directly facilitate the initial conversion. The other options, like cytochrome P450, are also involved in various metabolic processes, but they do not play a direct role in converting 7-dehydrocholesterol to vitamin D3 either. Aldose reductase specifically functions in carbohydrate metabolism and is unrelated to vitamin D synthesis. Thus, the enzyme that is primarily involved in these transformations is not

The conversion of 7-dehydrocholesterol to vitamin D3 primarily involves the action of UV light rather than a specific enzyme. When skin is exposed to sunlight, specifically ultraviolet B (UVB) radiation, 7-dehydrocholesterol undergoes a photochemical reaction to form previtamin D3, which then spontaneously isomerizes to vitamin D3 (cholecalciferol) at body temperature.

While hydroxylase enzymes are essential in the subsequent steps that convert vitamin D3 into its active forms in the liver and kidney, the original conversion from 7-dehydrocholesterol to vitamin D3 is not enzyme-mediated but rather a light-driven process. Therefore, while hydroxylases play crucial roles in the metabolic pathway of vitamin D, particularly during hydroxylation of the molecule in later steps, they do not directly facilitate the initial conversion.

The other options, like cytochrome P450, are also involved in various metabolic processes, but they do not play a direct role in converting 7-dehydrocholesterol to vitamin D3 either. Aldose reductase specifically functions in carbohydrate metabolism and is unrelated to vitamin D synthesis.

Thus, the enzyme that is primarily involved in these transformations is not